SS-31 (also known as Elamipretide) is a mitochondrial-targeted tetrapeptide (D-Arg-dimethylTyr-Lys-Phe-NH₂) being investigated in models of oxidative stress, mitochondrial dysfunction, and age-related cellular decline. Research interest in SS-31 has expanded due to its unique ability to localize to the inner mitochondrial membrane, where it interacts with cardiolipin and may influence mitochondrial bioenergetics in preclinical studies.

Compound Details

Name: SS-31 (Elamipretide)
Molecular Formula: C₄₉H₈₇N₁₃O₇
Molecular Weight: ~1023.3 g/mol
Form: Lyophilized peptide
Purity: ≥98% (HPLC verified)
Available Sizes: 10mg and 50mg vials
Storage: -20°C recommended. Avoid repeated freeze-thaw cycles. Use sterile procedures upon reconstitution.

Research Applications

Mitochondrial Function Studies
SS-31 is widely studied in the context of mitochondrial integrity. It selectively targets the inner mitochondrial membrane and binds to cardiolipin, a key phospholipid involved in maintaining mitochondrial cristae structure.
Oxidative Stress & Cellular Damage Models
In preclinical models, SS-31 has shown potential to stabilize mitochondrial respiration under oxidative conditions. Its ability to preserve ATP production and reduce reactive oxygen species (ROS) output is central to ongoing studies in metabolic stress, neurodegeneration, and ischemic tissue.
Age-Related Research
SS-31 has gained attention in aging biology for its role in cellular senescence studies and chronic mitochondrial dysfunction often associated with advanced age. Lab models have explored its effect on skeletal muscle performance and mitochondrial DNA damage response.
Ischemia-Reperfusion and Organ Protection
Investigations have also explored SS-31 in ischemia-reperfusion models for cardiac, renal, and hepatic tissues. Its use as a tool to assess mitochondrial preservation in response to acute oxygen deprivation and restoration is ongoing in controlled research environments.

Handling & Usage

Reconstitute using bacteriostatic water under sterile conditions
Store reconstituted solution at 2–8°C and use within 30 days
Do not expose to repeated temperature changes

Regulatory Notice

This product is strictly intended for laboratory research purposes only. It is not for human consumption and is not FDA-approved for therapeutic or diagnostic use. Use of this compound is limited to qualified professionals in controlled lab environments.

View test result: https://janoshik.com/tests/37696-SS31_50_mg_IAT5USWEZ3RJ